Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts through the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interaction... https://clintd453sai1.empirewiki.com/user