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Opioid action is because of both equally lower affinity binding on the guardian compound and higher affinity binding of your O-demethylated metabolite M1 to µ-opioid receptors. In animal versions, M1 is as many as 6 moments more powerful than tramadol in generating analgesia and two hundred situations a lot more https://benjamine666drg1.life3dblog.com/profile

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