Under problems of lower CB1R density, THC antagonises endogenous agonists possessing higher receptor efficacy than THC19. THC also allosterically modulates opioid receptors20, which may deliver supplemental oblique routes for altering dopamine transmission21. Also, THC has psychoactive metabolites with CB1R affinity, additional complicating the analyses of receptor binding studies22. ... https://cesarwelty.qodsblog.com/33029625/the-smart-trick-of-cannabinoids-that-nobody-is-discussing