Seizures and/serotonin syndrome may occur when employed concomitantly with serotonergic agents (SSRIs, SNRIs, and triptans) or with drugs that appreciably reduce the metabolic clearance of tramadol. Concomitant use or discontinuation of CYP450 isoenzymes which includes CYP450 3A4 inducers, CYP450 3A4 inhibitors, or CYP450 2D6 inhibitors are complicated; concomitant use involves https://shirino998itc9.robhasawiki.com/user